An Unusal Distribution of 6-nt Sequences Near The Transcription Start Site
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doi:10.2390/biecoll-jib-2008-103
June 19, 2008
August 25, 2008
PubMed ID 20134067
Chanchal K. Mitra and Luciano Milanesi
Correspondence should be addressed to:
Chanchal K Mitra
Department of Biochemistry, University of Hyderabad, Hyderabad 500 046, INDIA
moc.oohay@nullartim_c
Abstract
A new look at the transcription start is presented in which we can see transcription factors binding to both sides of the TSS as an essential requirement. Naturally the factor binding to the downstream region must be removed so that transcription process can continue. The presence of a number of distinct transcription factors also can be used to explain selective activation of various genes. The transcription start site by itself plays only a minor role in the whole process. We also suggest that mutations close to the TSS on the coding side can be fatal even if preserves the codon table.