An evaluation of the performance of three semantic background knowledge sources in comparative anatomy

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doi doi:10.2390/biecoll-jib-2010-124
submission February 19, 2010
published March 25, 2010
NCBI PubMed PubMed ID 20375449

Ernest AA van Ophuizen and Jack AM Leunissen

Correspondence should be addressed to:
Ernest van Ophuizen
Laboratory of Bioinformatics, Wageningen University, Droevendaalsesteeg 1, 6708PB, Wageningen, The Netherlands
ln.ruw@nullneziuhpOnav.tsenrE


Abstract

In this paper we evaluate the performance and usefulness of three semantic background knowledge sources for predicting synonymous anatomical terms across species boundaries. The reference sources under evaluation are UMLS, FMA-OBO and WordNet, which are applied to the anatomical ontologies of mouse and zebrafish. Our results show that the use of specialized knowledge sources leads to highly accurate predictions, verified through complete manual curation, which can be further improved by combining multiple of said sources. We argue that these three references complement each other in terms of granularity and specificity. From our results we conclude that these references can be used to create reliable ontology mappings with minimal human supervision.

Reference

Ernest AA van Ophuizen and Jack AM Leunissen. An evaluation of the performance of three semantic background knowledge sources in comparative anatomy. Journal of Integrative Bioinformatics, 7(3):124, 2010. Online Journal: http://journal.imbio.de/index.php?paper_id=124
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