Analysis and construction of pathogenicity island regulatory pathways in Salmonella enterica serovar Typhi

More Information | Back to archive
Full Text of this article Full article [PDF] (3,67 MB)
doi doi:10.2390/biecoll-jib-2010-145
submission May 25, 2010
published September 23, 2010
NCBI PubMed PubMed ID 20861532

Su Yean Ong, Fui Ling Ng, Siti Suriawati Badai, Anton Yuryev and Maqsudul Alam

Correspondence should be addressed to:
Su Yean Ong
Centre for Chemical Biology, Universiti Sains Malaysia, 1st Floor, Block B, No.10, Persiaran Bukit Jambul, 11900 Bayan Lepas, Pulau Pinang, Malaysia
moc.liamg@nullbccnaeyus


Abstract

Signal transduction through protein-protein interactions and protein modifications are the main mechanisms controlling many biological processes. Here we described the implementation of MedScan information extraction technology and Pathway Studio software (Ariadne Genomics Inc.) to create a Salmonella specific molecular interaction database. Using the database, we have constructed several signal transduction pathways in Salmonella enterica serovar Typhi which causes Typhoid Fever, a major health threat especially in developing countries. S. Typhi has several pathogenicity islands that control rapid switching between different phenotypes including adhesion and colonization, invasion, intracellular survival, proliferation, and biofilm formation in response to environmental changes. Understanding of the detailed mechanism for S. Typhi survival in host cells is necessary for development of efficient detection and treatment of this pathogen. The constructed pathways were validated using publically available gene expression microarray data for Salmonella.

Reference

Su Yean Ong, Fui Ling Ng, Siti Suriawati Badai, Anton Yuryev and Maqsudul Alam. Analysis and construction of pathogenicity island regulatory pathways in Salmonella enterica serovar Typhi. Journal of Integrative Bioinformatics, 7(1):145, 2010. Online Journal: http://journal.imbio.de/index.php?paper_id=145
imprint | sitemap | credits | top