Reconstruction of biological networks based on life science data integration

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doi doi:10.2390/biecoll-jib-2010-146
submission November 04, 2009
last revision August 23, 2010
published October 27, 2010
NCBI PubMed PubMed ID 20978286

Benjamin Kormeier, Klaus Hippe, Patrizio Arrigo, Thoralf Töpel, Sebastian Janowski and Ralf Hofestädt

Correspondence should be addressed to:
Benjamin Kormeier
Bielefeld University, Bioinformatics Department, PO Box 10 01 31, 33615 Bielefeld, Germany
ed.dlefeleib-inu.kafhcet@nulleiemrokb


Abstract

For the implementation of the virtual cell, the fundamental question is how to model and simulate complex biological networks. Therefore, based on relevant molecular database and information systems, biological data integration is an essential step in constructing biological networks. In this paper, we will motivate the applications BioDWH - an integration toolkit for building life science data warehouses, CardioVINEdb - a information system for biological data in cardiovascular-disease and VANESA- a network editor for modeling and simulation of biological networks. Based on this integration process, the system supports the generation of biological network models. A case study of a cardiovascular-disease related gene-regulated biological network is also presented.

Reference

Benjamin Kormeier, Klaus Hippe, Patrizio Arrigo, Thoralf Töpel, Sebastian Janowski and Ralf Hofestädt. Reconstruction of biological networks based on life science data integration. Journal of Integrative Bioinformatics, 7(2):146, 2010. Online Journal: http://journal.imbio.de/index.php?paper_id=146
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