A generic organ based ontology system, applied to vertebrate heart anatomy, development and physiology

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doi doi:10.2390/biecoll-jib-2011-167
submission April 30, 2011
last revision August 18, 2011
published September 08, 2011
NCBI PubMed PubMed ID 21900708

Laura M. F. Bertens, Joris Slob and Fons J. Verbeek

Correspondence should be addressed to:
Fons Verbeek
Imaging & Bioinformatics, LIACS, Leiden University, The Netherlands
ln.scail@nullkeebrevf


Abstract

We present a novel approach to modelling biological information using ontologies. The system interlinks three ontologies, comprising anatomical, developmental and taxonomical information, and includes instances of structures for different species. The framework is constructed for comparative analyses in the field of evolutionary development. We have applied the approach to the vertebrate heart and present four case studies of the functionality of the system, focusing on cross-species comparisons, developmental studies, physiological studies and 3D visualisation.

Reference

Laura M. F. Bertens, Joris Slob and Fons J. Verbeek. A generic organ based ontology system, applied to vertebrate heart anatomy, development and physiology. Journal of Integrative Bioinformatics, 8(2):167, 2011. Online Journal: http://journal.imbio.de/index.php?paper_id=167
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