Model Reference Adaptive Scheme for Multi-drug Infusion for Blood Pressure Control

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doi doi:10.2390/biecoll-jib-2011-173
submission July 08, 2011
published September 15, 2011
NCBI PubMed PubMed ID 21926436

Saleh Enbiya, Fatima Mahieddine and Alamgir Hossain

Correspondence should be addressed to:
Saleh Enbiya
School of Computing, Informatics and Media, University of Bradford, UK
ku.ca.drofdarb@nullayibnes


Abstract

Using multiple interacting drugs to control both the mean arterial pressure (MAP) and cardiac output (CO) of patients with different sensitivity to drugs is a challenging task which this paper attempts to address. A multivariable model reference adaptive control (MRAC) algorithm is developed using a two-input, two-output patient model. The control objective is to maintain the homodynamic variables MAP and CO at the normal values by simultaneously administering two drugs; sodium nitroprusside (SNP) and dopamine (DPM). Computer simulations were carried out to investigate the performance of this controller. The results show that the proposed adaptive scheme is robust with respect to disturbances and variations in model parameters.

Reference

Saleh Enbiya, Fatima Mahieddine and Alamgir Hossain. Model Reference Adaptive Scheme for Multi-drug Infusion for Blood Pressure Control. Journal of Integrative Bioinformatics, 8(3):173, 2011. Online Journal: http://journal.imbio.de/index.php?paper_id=173
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