Oncology In Vivo Data Integration for Hypothesis Generation
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doi:10.2390/biecoll-jib-2012-193
May 16, 2012
July 09, 2012
PubMed ID 22773158
Jia Wei and Ming Chen
Correspondence should be addressed to:
Jia Wei
AstraZeneca Innovation Center China, R&D Information China, Building 7, No.898 Halei Road, Zhangjiang Hi-Tech Park, Shanghai 201203, China
moc.acenezartsa@nulliew.ynnej
Abstract
AstraZeneca’s Oncology in vivo data integration platform brings multidimensional data from animal model efficacy, pharmacokinetic and pharmacodynamic data to animal model profiling data and public in vivo studies. Using this platform, scientists can cluster model efficacy and model profiling data together, quickly identify responder profiles and correlate molecular characteristics to pharmacological response. Through meta-analysis, scientists can compare pharmacology between single and combination treatments, between different drug scheduling and administration routes.