Noise in Genetic Toggle Switch Models

M. Andrecut and S. A. Kauffman

Correspondence should be addressed to:
M. Andrecut
Institute for Biocomplexity and Informatics, University of Calgary, Alberta, T2N 1N4, Canada
ac.yraglacu@nullucerdnam

Abstract

In this paper we study the intrinsic noise effect on the switching behavior of a simple genetic circuit corresponding to the genetic toggle switch model. The numerical results obtained from a noisy mean-field model are compared to those obtained from the stochastic Gillespie simulation of the corresponding system of chemical reactions. Our results show that by using a two step reaction approach for modeling the transcription and translation processes one can make the system to lock in one of the steady states for exponentially long times.

Reference

M. Andrecut and S. A. Kauffman. Noise in Genetic Toggle Switch Models. Journal of Integrative Bioinformatics, 3(1):23, 2006. Online Journal: http://journal.imbio.de/index.php?paper_id=23