Flexible web-based integration of distributed large-scale human protein interaction maps

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doi doi:10.2390/biecoll-jib-2007-51
submission November 15, 2006
published February 26, 2007

Gautam Chaurasia, Yasir Iqbal, Christian Hänig, Hanspeter Herzel, Erich E. Wanker and Matthias E. Futschik

Correspondence should be addressed to:
Gautam Chaurasia
Invalidenstr 43, 10115, Berlin, Germany
ed.nilreb-uh.eigoloib@nullaisaruahc.g


Abstract

Protein-protein interactions constitute the backbone of many molecular processes. This has motivated the recent construction of several large-scale human protein-protein interaction maps [1-10]. Although these maps clearly offer a wealth of information, their use is challenging: complexity, rapid growth, and fragmentation of interaction data hamper their usability. To overcome these hurdles, we have developed a publicly accessible database termed UniHI (Unified Human Interactome) for integration of human protein-protein interaction data. This database is designed to provide biomedical researchers a common platform for exploring previously disconnected human interaction maps. UniHI offers researchers flexible integrated tools for accessing comprehensive information about the human interactome. Several features included in the UniHI allow users to perform various types of network-oriented and functional analysis. At present, UniHI contains over 160,000 distinct interactions between 17,000 unique proteins from ten major interaction maps derived by both computational and experimental approaches [1-10]. Here we describe the details of the implementation and maintenance of UniHI and discuss the challenges that have to be addressed for a successful integration of interaction data.

Reference

Gautam Chaurasia, Yasir Iqbal, Christian Hanig, Hanspeter Herzel, Erich E. Wanker and Matthias E. Futschik. Flexible web-based integration of distributed large-scale human protein interaction maps. Journal of Integrative Bioinformatics, 4(1):51, 2007. Online Journal: http://journal.imbio.de/index.php?paper_id=51
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